"This heart didn't come with instructions," he posted on Monday.
Mayer's heart has been all over the place during his time with Aniston, 40: They broke up two times in 13 months.
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In August 2008, they first called it quits. At the time Mayer blabbed about the split to paparazzi outside his NYC gym, stressing that he was the one who broke things off.
"I ended a relationship to be alone because I don't want to waste somebody's time if something's not right," he said.
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They got back together and even attended the Oscars together last month.
See Jennifer and John getting cozy at an Oscar bash
"You have to really be with someone that you know who has your back in that situation," he said of attending the show with her.
Alas, they split a short time later.